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ACE-Inhibitor
Microcystins
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>Background
ACE catalyses the conversion of angiotensin I into angiotensin II within the mammalian renin-angiotensin system, leading to arterial stenosis, which in turn causes an increase of blood pressure. ACE inhibitors counteract this process and therefore play a major role in human medicine as blood pressure lowering agents. There are already a number of naturally occurring microginin-variants with inhibitory effects coming close to those of commercially available ACE-Inhibitors. So far approx. 30 structural variants of microginin are known. In Microcystis aeruginosa a cluster of genes, spanning 30 kbps, encodes a hybrid synthetase composed of NRPS, PKS and tailoring enzymes that is responsible for the biosynthesis of microginin. Microginins are pentapeptides with the chemical structure Ahda-X-Z-Tyr-Tyr, with X and Z being variable amino acids.
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