Selected publications

Rantala A., D. P. Fewer, M. Hisbergues, L. Rouhiainen, J. Vaitomaa, T. Börner, K. Sivonen (2004) Phylogenetic evidence for the early evolution of microcystin synthesis. Proc. Natl. Acad. Sci. USA 101: 568-573

Welker M, Brunke M, Preussel K, Lippert I, von Döhren H. (2004) Diversity and distribution of Microcystis (Cyanobacteria) oligopeptide chemotypes from natural communities studied by single-colony mass spectrometry, Microbiology 150(Pt 6):1785-96.

Sielaff, H., N. Tandeau de Marsac, C. Bouchier, E. Dittmann, H. von Döhren, T. Börner, T. Schwecke (2003) The mcyF gene of the microcystin biosynthetic gene cluster from Microcystis aeruginosa encodes an aspartate racemase. Biochem J. 373: 903-916

Hisbergues M, Christiansen G, Rouhiainen L, Sivonen K, Börner T. (2003) PCR-based identification of microcystin-producing genotypes of different cyanobacterial genera. Arch Microbiol. 180(6):402-10.

Kurmayer R, Christiansen G, Chorus I. (2003) The abundance of microcystin-producing genotypes correlates positively with colony size in Microcystis sp. and determines its microcystin net production in Lake Wannsee. Appl Environ Microbiol. 69(2):787-95.

Christiansen G, Fastner J, Erhard M, Börner T, Dittmann E. (2003) Microcystin biosynthesis in planktothrix: genes, evolution, and manipulation., J Bacteriol. 185(2):564-72.

Kaebernick, M., E. Dittmann, T. Börner, B.A. Neilan (2002) Multiple alternate transcripts direct the biosynthesis of microcystin, a cyanobacterial non-ribosomal peptide. Appl.Env. Microbiol. 68: 449-455

Pan, H., L. Song, Y. Liu, T. Börner (2002) Detection of hepatotoxic Microcystis strains by PCR with intact cells from both culture and environmental samples. Arch. Microbiol. 178: 421-427

Welker M, Fastner J, Erhard M, von Döhren H. (2002) Applications of MALDI-TOF MS analysis in cyanotoxin research, Environ Toxicol. 17(4):367-74.

Dieckmann, R. and Schwecke, T. (2002) Modular Polyketide Synthases. Review in: Polymers, Wiley-VCH, Weinheim, A. Steinbüchel (ed.):89-111.

Christiansen G, Dittmann E, Via Ordorika L, Rippka R, Herdman M, Borner T. (2001) Nonribosomal peptide synthetase genes occur in most cyanobacterial genera as evidenced by their distribution in axenic strains of the PCC. Arch Microbiol. 176(6):452-8. Epub 2001 Sep 27.

Rohrlack, T., Dittmann, E., Börner, T., Christoffersen, K. (2001) Effects of cell-bound microcystins on survival and feeding of Daphnia spp. Appl. Environ. Microbiol. 67: 3523-3529

Hesse, K., E. Dittmann, T. Börner (2001) Consequences of impaired microcystin production for light-dependent growth and pigmentation of Microcystis aeruginosa PCC 7806. FEMS Microbiol. Ecol. 37:39-43

Dittmann, E., M. Erhard, M. Kaebernick, C. Scheler, B.A. Neilan, H. von Döhren, T. Börner (2001) Altered expression of two light-dependent genes in a microcystin-lacking mutant of Microcystis aeruginosa PCC 7806. Microbiology 147:3113-3119

Dittmann, E., B.A. Neilan, T. Börner (2001) Molecular biology of peptide and polyketide biosynthesis in cyanobacteria. Appl. Microbiol. Biotechnol. 57:467-473

Fastner J, Erhard M, von Döhren H. (2001) Determination of oligopeptide diversity within a natural population of Microcystis spp. (cyanobacteria) by typing single colonies by matrix-assisted laser desorption ionization-time of flight mass spectrometry, Appl Environ Microbiol. 67(11):5069-76.

Kaebernick, M., B. Neilan, T. Börner, E. Dittmann (2000) Light and the transcriptional response of the microcystin biosynthetic gene cluster. Appl. Environ. Microbiol. 66: 3387-3392

Tillett, D., E. Dittmann, M. Erhard, H. von Döhren, T. Börner, B. Neilan (2000) Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC 7806: An integrated peptide-polyketide synthetase system. Chem. Biol. 7:753-764

Rohrlack, T. , E. Dittmann, M. Henning, T. Börner, J.-G. Kohl (1999) Role of microcystins in poisoning and food ingestion inhibition of Daphnia galatea caused by the cyanobacterium Microcystis aeruginosa. Appl. Environ. Microbiol. 65:737-739

Neilan, B.A., E. Dittmann, L. Rouhianinen, R. A. Bass, K. Sivonen, T. Börner (1999) Non-ribosomal peptide synthesis and the toxigenicity of cyanobacteria. J. Bact. 181:4089-4097

von Döhren H, Dieckmann R, Pavela-Vrancic M. (1999) The nonribosomal code, Chem Biol. 6(10):R273-9. Review.

Kleinkauf H, von Döhren H. (1997) Applications of peptide synthetases in the synthesis of peptide analogues, Acta Biochim Pol. 44(4):839-47. Review.

Dittmann E, Neilan BA, Erhard M, von Döhren H, Börner T. (1997) Insertional mutagenesis of a peptide synthetase gene that is responsible for hepatotoxin production in the cyanobacterium Microcystis aeruginosa PCC 7806, Mol Microbiol. 26(4):779-87.

Erhard M, von Döhren H, Jungblut P. (1997) Rapid typing and elucidation of new secondary metabolites of intact cyanobacteria using MALDI-TOF mass spectrometry. Nat Biotechnol. 15(9):906-9.

von Döhren H. (1997) Genetics on the move into natural-product chemistry. Trends Biotechnol. 15(4):117-9.

Kleinkauf H, von Döhren H. (1997) Enzymatic generation of complex peptides. Prog Drug Res. 48:27-53. Review.

König A, Schwecke T, Molnar I, Böhm GA, Lowden PA, Staunton J, and Leadlay PF, (1997) The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin-nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus. Eur. J. Biochem. 247 (2), 526-34.

Kleinkauf H, von Döhren H. (1996) A nonribosomal system of peptide biosynthesis. Eur J Biochem. 236(2):335-51. Review.

Meißner, K., E. Dittmann, T. Börner (1996) Toxic and nontoxic strains of the cyanobacterium Microcystis aeruginosa contain sequences homologous to peptide synthetase genes. FEMS Microbiol. Lett. 135:295-303

Dittmann, E., K. Meißner, T. Börner (1996) Conserved sequences of peptide synthetase genes in the cyanobacterium Microcystis aeruginosa. Phycologia 35 No. 6 ( Suppl.):62-67.

Schwecke T, Aparicio JF, Molnar I, König A, Khaw LE, Haydock SF, Oliynyk M, Caffrey P, Cortes J, Lester JB, Böhm, GA, Staunton J, and Leadlay PF, (1995) The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. Proc. Natl. Acad. Sci. U S A. 92 (17), 7839-43.

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